A common treatment of atherosclerosis, one of the most common cardiovascular diseases, involves the placement of a bypass made of synthetic grafts, such as Dacron or Gore-Tex. However, an important mismatch in the mechanical properties between the native tissue and the graft can result in complications, especially for small-diameter vessels (<6mm). Therefore, detailed analysis of the global and local mechanical properties of synthetic graft materials, in comparison to native tissue, is essential to further improve vascular graft properties and reducing the risk of graft failure. In this study, we applied 4D X-ray microfocus computed tomography (4D XCT) to a Dacron graft. Local strain maps were calculated based on conventional Digital Volume Correlation (DVC)and three different methods of incremental DVC were compared.