Growth hormone gene regulation by trans-acting factors.

Rousseau, Guy
(1992) Hormone Research — Vol. 37 Suppl 3, p. 88-92 (1992)

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  • Rousseau, GuyUCLouvain
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Abstract
The promoter sequence of the growth hormone (GH) gene binds the ubiquitous factors nuclear factor 1, activator protein-2, upstream stimulatory factor and Sp1. A pituitary-specific factor known as growth hormone factor 1 or Pit-1 also binds to the promoter sequence. This factor is responsible for somatotroph-specific expression of GH. It is also involved in the effect of GH-releasing hormone and in the ontogeny of the anterior pituitary.
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Rousseau, G. (1992). Growth hormone gene regulation by trans-acting factors. Hormone Research, 37 Suppl 3, 88-92. https://doi.org/10.1159/000182407 (Original work published 1992)