Highly chemoselective reduction of carbonyl groups in the presence of aldehydes

Bastug, Gulluzar;Dierick, Steve;Lebreux, Frédéric;Marko, Istvan
(2012) Organic Letters — Vol. 14, n° 5, p. 1306-1309 (2012)

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Authors
  • Bastug, GulluzarUCLouvain
    Author
  • Dierick, SteveUCLouvain
    Author
  • Lebreux, FrédéricScientific & Regulatory Affairs Manager at IFRA (International Fragrance Association)
    Author
  • Marko, IstvanUCLouvain
    Author
Abstract
The exquisite ability of diethylaluminum benzenethiolate to efficiently discriminate between aldehydes and other carbonyl functions enables the chemoselective in situ reduction of ketones and Me esters in the presence of aldehydes. This potent strategy avoids the usual drawbacks of traditional protecting group methodologies and could be extended to various other transformations.
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Bastug, G., Dierick, S., Lebreux, F., & Marko, I. (2012). Highly chemoselective reduction of carbonyl groups in the presence of aldehydes. Organic Letters, 14(5), 1306-1309. https://doi.org/10.1021/ol300188e (Original work published 2012)