[18F]CuCF3: A [18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides

Ivashkin, Pavel;Lemonnier, Gérald;Cousin, Jonathan;Grégoire, Vincent;Pannecoucke, Xavier;et.al.
(2014) Chemistry: A European Journal — Vol. 20, n° 31, p. 9514-9518 (2014)

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Authors
  • Ivashkin, PavelCNRS, France
    Author
  • Lemonnier, GéraldCNRS, France
    Author
  • Cousin, JonathanCNRS, France
    Author
  • Grégoire, VincentUCLouvain
    Author
  • Labar, DanielUCLouvain
    Author
  • Pannecoucke, XavierCNRS, France
    Author
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Abstract
Positron emission tomography has emerged as the leading method for medical imaging with fluorine-18 as the most widely used radioactive isotope. Here we report a semi-automated method for the preparation of valuable [18F]trifluoromethylcopper, as well as its use for the radiosynthesis of [18F]trifluoromethylarenes and heteroarenes. Mild conditions of [18F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [18F]trifluoromethylarenes and heteroarenes.
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Ivashkin, P., Lemonnier, G., Cousin, J., Grégoire, V., Labar, D., Jubault, P., & Pannecoucke, X. (2014). [18F]CuCF3: A [18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides. Chemistry: A European Journal, 20(31), 9514-9518. https://doi.org/10.1002/chem.201403630 (Original work published 2014)