Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination.
(2016) The Journal of Physiology — Vol. 594, n° 17, p. 4849-4863 (2016)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- Using recombinant DNA technology, the present study provides the first strong and direct evidence indicating that β-alanine is an efficient substrate for the mammalian transaminating enzymes 4-aminobutyrate-2-oxoglutarate transaminase and alanine-glyoxylate transaminase. The concentration of carnosine and anserine in murine skeletal and heart muscle depends on circulating availability of β-alanine, which is in turn controlled by degradation of β-alanine in liver and kidney. Chronic oral β-alanine supplementation is a popular ergogenic strategy in sports because it can increase the intracellular carnosine concentration and subsequently improve the performance of high-intensity exercises. The present study can partly explain why the β-alanine supplementation protocol is so inefficient, by demonstrating that exogenous β-alanine can be effectively routed toward oxidation.
- Affiliations
Citations
Blancquaert, L., Baba, S. P., Kwiatkowski, S., Stautemas, J., Stegen, S., Barbaresi, S., Chung, W., Boakye, A. A., Hoetker, J. D., Bhatnagar, A., Delanghe, J., Vanheel, B., Veiga da Cunha, M., Derave, W., & Everaert, I. (2016). Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β-alanine transamination. The Journal of Physiology, 594(17), 4849-4863. https://doi.org/10.1113/JP272050 (Original work published 2016)