Tetrathiatriarylmethyl radicals conjugated to an RGD-peptidomimetic

Driesschaert, Benoît;Levêque, Philippe;Gallez, Bernard;Marchand-Brynaert, Jacqueline
(2014) European Journal of Organic Chemistry — Vol. 2014, n° 36, p. 8077-8084 (2014)

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Authors
  • Driesschaert, BenoîtUCLouvain
    Author
  • Levêque, PhilippeUCLouvain
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  • Gallez, Bernardorcid-logoUCLouvain
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  • Marchand-Brynaert, JacquelineUCLouvain
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Abstract
Tetrathiatriarylmethyl (TAM) radicals are favourite spin labels for electron paramagnetic resonance imaging (EPRI). In this work, we report a straightforward synthesis of new TAM radicals bound to an Arg-Gly-Asp (RGD)-peptido-mimetic known to be a cell-targeting agent. These new radicals are stable in solution, and sensitive to oxygen, and their experimental EPR data is consistent with density functional theory (DFT) calculations.
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Driesschaert, B., Levêque, P., Gallez, B., & Marchand-Brynaert, J. (2014). Tetrathiatriarylmethyl radicals conjugated to an RGD-peptidomimetic. European Journal of Organic Chemistry, 2014(36), 8077-8084. https://doi.org/10.1002/ejoc.201403049 (Original work published 2014)