Nouveaux anti-épileptiques : quelle toxicité en cas d’intoxication aiguë ?
(2005) Journal Europeen des Urgences — Vol. 18, n° 4, p. 221-226 (2005)
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- (en) [How toxic is an overdose of the newer generation anti-epileptic drugs?] New anti-epileptic drugs (AED) have become available over the last years. Anti-epileptic drugs are still common substances taken in intentional drug overdoses. The data collected from the US poison control centres show that the mortality and morbidity remain high after acute poisoning due to the older anti-epileptics, and particularly with valproic acid. The objective of this short review is to discuss the safety profile of seven recent AED : topiramate, vigabatrin, tiagabine, gabapentine, levetiracetam, felbamate, lamotrigine and oxcarbazepine. It appears from the recent case reports or from the limited number of case series, that acute poisoning with the newer AED results in an extremely low mortality and morbidity. As expected, a short-lasting central nervous system depression is a common finding, but few patients require mechanical ventilation. Seizures are occasionally observed. Serious cardiovascular events have been reported in a very few cases. Treatment is mainly suppportive.
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Hantson, P. (2005). Nouveaux anti-épileptiques : quelle toxicité en cas d’intoxication aiguë ? Journal Europeen des Urgences, 18(4), 221-226. https://doi.org/10.1016/s0993-9857(05)82498-7 (Original work published 2005)