High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation for adult histiocytic disorders with central nervous system involvement
(2006) Haematologica : the hematology journal — Vol. 91, n° 8, p. 1121-1125 (2006)
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- We postulated that high-dose chemotherapy (HDC) followed by peripheral autologous hematopoietic stem cell transplantation might help to control refractory central nervous system (CNS) histiocytic disorders. Six patients with histiocytic CNS involvement were treated in this way. Two patients achieved non-active disease status, although one relapsed at 84 months. Two patients had regressive disease, one of whom progressed at 21 months. One patient had progressive disease at 14 months. One patient had extra-CNS progression but CNS regression. After a median follow-up of 22.4 months, only one of the six patients still has non-active disease. Treatment was effective on craniofacial and space-occupying brainstem lesions, and was ineffective on neurodegenerative lesions.
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Gaspar, N., Van Den Neste, E., Boudou, P., Haroche, J., Wechsler, B., Hoang-Xuan, K., Amoura, Z., Guillevin, R., Savatovski, J., Azar, N., Piette, J.-C., & Leblond, V. (2006). High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation for adult histiocytic disorders with central nervous system involvement. Haematologica : the hematology journal, 91(8), 1121-1125. https://hdl.handle.net/2078.5/35947 (Original work published 2006)