[Present trends in cancer therapy with high-LET radiations]
(1996) 7th Meeting on Irradiation Chemistry — Location: CAEN (France) (5.September.1994)
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- Abstract
- Application of high-LET radiations in cancer therapy is based on radiobiological arguments : great efficiency against hypoxic cancer cells, or cells in resistant phases of the mitotic cycle or quiescent. However, from a clinical point of view, the problem of the selection of patients who could benefit from high-LET radiations is not solved. Clinical observation shows that high-LET radiations bring a benefit for certain types of rumours : salivary glands, antrum, prostate, sarcomas, etc. These rumours are, in general, slowly growing, well differentiated and resistant to conventional x-rays as well as chemotherapy. Among high-LET radiations, fast neutrons have been most widely used. Today, neutrons can be applied in technical conditions, and with a allow the radiotherapist to apply high-LET radiations with an excellent physical selectivity. Unfortunately, the complexity of the equipment and mainly the cost prevented the development of the technique.
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Citations
Wambersie, A., Grégoire, V., & Gueulette, J. (1996). [Present trends in cancer therapy with high-LET radiations]. Journal de Chimie Physique, 93(1), 244-252. https://hdl.handle.net/2078.5/42418 (Original work published 1996)