Hypoxic Training Improves Normoxic Glucose Tolerance in Adolescents with Obesity :
(2018) Medicine & Science in Sports & Exercise — Vol. 50, n° 11, p. 2200-2208 (2018)
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- Abstract
- PURPOSE: To test whether environmental hypoxia could potentiate the effects of exercise training on glucose metabolism and insulin sensitivity. METHODS: Fourteen adolescents with obesity were assigned to 6 weeks of exercise training either in normoxic or in hypoxic conditions (FiO2 15%). Adolescents trained 3x/w for 50-60min, including endurance and resistance exercises. Oral glucose tolerance test (OGTT), blood and morphological analyses as well as physical performance tests were performed before and after the training period. RESULTS: After training, hypoxia, but not normoxia, decreased the area under the curve of plasma insulin (-49%; p=0.001) and glucose levels (-14%; p=0.005) during OGTT. Decreased plasma triglycerides levels (p=0.03) and increased maximal aerobic power (p=0.002), work capacity at 160 beats/min (p=0.002) and carbohydrate consumption during exercise (p=0.03) were measured only in the hypoxic group. CONCLUSIONS: Hypoxic exercise training was particularly efficient at improving glucose tolerance and insulin response to a glucose challenge in adolescents with obesity. These results suggest that exercise training in hypoxia could be an interesting strategy against insulin resistance and type 2 diabetes development in adolescents with obesity.
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De Groote, E., Britto, F. A., Bullock, L., François, M., De Buck, C., Nielens, H., & Deldicque, L. (2018). Hypoxic Training Improves Normoxic Glucose Tolerance in Adolescents with Obesity : Medicine & Science in Sports & Exercise, 50(11), 2200-2208. https://doi.org/10.1249/mss.0000000000001694 (Original work published 2018)