Coregistered mismatch volume and cortical location of infarction were the important factors associated with presence of the classical mismatch pattern. The lack of effect of the type of mismatch patterns on infarct growth, clinical outcomes, or the benefit of t-PA would suggest that mismatch topography is less important during the hyperacute phase of ischemic stroke than during subacute phase.
Ogata, T., Nagakane, Y., Christensen, S., Ma, H., Campbell, B. C. V., Churilov, L., Olivot, J.-M., Desmond, P. M., Albers, G. W., Davis, S. M., & Donnan, G. A. (2011). A topographic study of the evolution of the MR DWI/PWI mismatch pattern and its clinical impact: a study by the EPITHET and DEFUSE Investigators. Stroke : a journal of cerebral circulation, 42(6), 1596-1601. https://doi.org/10.1161/STROKEAHA.110.609016 (Original work published 2011)