Acute megakaryoblastic leukemia and loss of the RUNX1 gene
(2006) Cancer Genetics and Cytogenetics — Vol. 164, n° 1, p. 71-73 (2006)
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- Abstract
- Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent numerical chromosome anomaly in acute megakaryoblastic leukemia (AMLK), a systematic study of RUNX1 abnormalities was performed by fluorescence in situ hybridization in AMLK patients. Four abnormalities were detected among 15 patients. One copy of RUNX1 was completeley or partially lost in three patients and translocated onto Xq24 in the fourth. The possible consequences of RUNX1 haploinsufficiency are discussed. (c) 2006 Elsevier Inc. All rights reserved.
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Citations
Berger, P., Michaux, L., Busson, M., Dastugue, N., Radford-Weiss, I., Hagemeijer, A., Quilichini, B., Benattar, L., Bernard, O., & Romana, S. (2006). Acute megakaryoblastic leukemia and loss of the RUNX1 gene. Cancer Genetics and Cytogenetics, 164(1), 71-73. https://doi.org/10.1016/j.cancergencyto.2005.05.002 (Original work published 2006)