Cyclopropanation de vinyl-métaux : application à la synthèse de produits naturels
(2009)
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- Authors
- Supervisors
- Marko, Istvan
- Abstract
- (en) Even though the cyclopropane ring is highly strained, it is found in a wide variety of natural products such as Dictyopterene A, a sexual pheromone isolated from brown algae, FR-900848, a strong antifungal compound and U-106305, a cholesteryl ester transfer protein inhibitor. Dictyopterene A has been prepared both in a racemic and enantioselective manner. One of the key-steps of these syntheses involves a methodology developped in our laboratory and based upon the regio- and diastereoselective cyclopropanation of dienylboronates. The second part of our thesis focused on the preparation of disubstituted cyclopropane buidling blocks, using a similar cylopropanation step. Selective coupling reactions on these compounds should lead to a modular synthesis of polycyclopropanes such as U-106305 and FR-900848.
- Affiliations
Citations
Marchant, M. (2009). Cyclopropanation de vinyl-métaux : application à la synthèse de produits naturels. https://hdl.handle.net/2078.5/74704