Massive bone allograft decellularization by a perfusion protocol set up for a biocompatible model

Evrard, Robin;Maistriaux, Louis;Manon, Julie;Rafferty, Chiara;Schubert, Thomas;et.al.
(2023) The International Combined Orthopaedic Research Societies (ICORS), World Congress of Orthopaedic Research — Location: (Scotland) Edinburgh (7.September.2022)

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Abstract
The purpose of this study is to enhance massive bone allografts osseointegration used to reconstruct large bone defects. These allografts show >50% complication rate requiring surgical revision in 20% cases. A new protocol for total bone decellularisation exploiting the vasculature can offer a reduction of postoperative complication by annihilating immune response and improving cellular colonization/ osseointegration. [...]
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Evrard, R., Maistriaux, L., Manon, J., Rafferty, C., Cornu, O., Gianello, P., Lengelé, B., & Schubert, T. (2023). Massive bone allograft decellularization by a perfusion protocol set up for a biocompatible model. Journal of Bone and Joint Surgery. British Volume. Orthopaedic Proceedings, 105-B(SUPP_7), 40. https://doi.org/10.1302/1358-992x.2023.7.040 (Original work published 2023)