Demyelinating sensorimotor polyneuropathy associated with the use of sirolimus : a case report.
(2008) Transplantation Proceedings — Vol. 40, n° 5, p. 1545-1547 (2008)
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- Abstract
- Liver transplantation is associated with a number of neurological complications. We herein report a case of chronic inflammatory demyelinating polyneuropathy associated with the use of sirolimus-based immunosuppression. The patient was treated by converting the immunosuppression from sirolimus to cyclosporine and by a short course of oral steroids. Following this, we observed almost complete clinical and electrophysiologic resolution of this syndrome. We believe that this is the first described case of such a complication occurring in association with sirolimus. This immunosuppressive agent can, therefore, lead to neurological complications similar to the ones that have been observed with calcineurin inhibitors.
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Bilodeau, M., Hassoun, Z., & Brunet, D. (2008). Demyelinating sensorimotor polyneuropathy associated with the use of sirolimus : a case report. Transplantation Proceedings, 40(5), 1545-1547. https://doi.org/10.1016/j.transproceed.2008.03.094 (Original work published 2008)