Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial).
(2011) BMC Anesthesiology — Vol. 11, n° 1, p. 11 (2011)
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- Pre- and postconditioning describe mechanisms whereby short ischemic periods protect an organ against a longer period of ischemia. Interestingly, short ischemic periods of a limb, in itself harmless, may increase the ischemia tolerance of remote organs, e.g. the heart (remote conditioning, RC). Although several studies have shown reduced biomarker release by RC, a reduction of complications and improvement of patient outcome still has to be demonstrated. Atrial fibrillation (AF) is one of the most common complications after coronary artery bypass graft surgery (CABG), affecting 27-46% of patients. It is associated with increased mortality, adverse cardiovascular events, and prolonged in-hospital stay. We hypothesize that remote ischemic pre- and/or post-conditioning reduce the incidence of AF following CABG, and improve patient outcome.
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Brevoord, D., Hollmann, M. W., De Hert, S. G., van Dongen, E. H., Heijnen, B. G., de Bruin, A., Tolenaar, N., Schlack, W. S., Weber, N. C., Dijkgraaf, M. G., de Groot, J. R., de Mol, B. A., Driessen, A. H., Momeni, M., Wouters, P., Bouchez, S., Hofland, J., Lüthen, C., Meijer-Treschan, T. A., et al. (2011). Effect of remote ischemic conditioning on atrial fibrillation and outcome after coronary artery bypass grafting (RICO-trial). BMC Anesthesiology, 11(1), 11. https://doi.org/10.1186/1471-2253-11-11 (Original work published 2011)