Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine in the B-cell leukemia cell line EHEB.
(2006) Nucleosides, nucleotides & nucleic acids — Vol. 25, n° 9-11, p. 1009-1012 (2006)
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- Abstract
- 2-Chloro-2'-deoxyadenosine (CdA) is a nucleoside analogue active in B-cell chronic lymphocytic leukemia (B-CLL). Although the mechanism of action of CdA has been extensively investigated in leukemic cells, the possibility that this nucleoside analogue interacts with the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway has never been explored. In this study, we show that CdA, at concentrations close to the IC50, activated the ERK pathway in the B-cell line EHEB. Because activation of this pathway is assumed to exert anti-apoptotic effect, we combined CdA with inhibitors of the ERK pathway. The latter were found to enhance CdA-induced apoptosis. These results suggest that the efficacy of CdA could be strengthened by combination with inhibitors of the ERK pathway.
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Citations
Smal, C., Lisart, S., Ferrant, A., Bontemps, F., & Van Den Neste, E. (2006). Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2′-deoxyadenosine in the B-cell leukemia cell line EHEB. Nucleosides, nucleotides & nucleic acids, 25(9-11), 1009-1012. https://doi.org/10.1080/15257770600894311 (Original work published 2006)