Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

Yous, Saïd;Lebegue, Nicolas;Poupaert, Jacques;Chavatte, Philippe;Berthelot, Pascal
(2005) Journal of Enzyme Inhibition and Medicinal Chemistry — Vol. 20, n° 6, p. 525-532 (2005)

Files

38943.pdf
  • Restricted Access
  • Adobe PDF
  • 263.01 KB
Request a copy

Details

Authors
  • Yous, Saïd
    Author
  • Lebegue, Nicolas
    Author
  • Poupaert, JacquesUCLouvain
    Author
  • Chavatte, Philippe
    Author
  • Berthelot, Pascal
    Author
Abstract
Fifteen compounds derived from the 2( 3H)-benzothiazolone template with an acyl side-chain in position-6 were evaluated for their lipid-lowering action in mice. Among these compounds, 6-benzoyl-2( 3H)-benzothiazolone was found to be the most potent one both in mice models receiving a hypercholesterolemic diet ( for 15 days) or a standard diet ( for 21 days). 6-Benzoyl-2( 3H)-benzothiazolone compares favorably with fenofibrate, the standard drug, both in terms of HDL-C/Chol ( High Density Lipoprotein-Cholesterol/Total Cholesterol) ratio and absence of liver hepatomegaly.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Yous, S., Lebegue, N., Poupaert, J., Chavatte, P., & Berthelot, P. (2005). Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds. Journal of Enzyme Inhibition and Medicinal Chemistry, 20(6), 525-532. https://doi.org/10.1080/03067310500212037 (Original work published 2005)