Impact of Akkermansia muciniphila and the intestinal endocannabinoid system on the metabolic syndrome
(2017)
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2017-06-14-HubertPlovier-ManuscritThèsedéfinitif.pdf
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Details
- Authors
- Supervisors
- Cani, Patrice
- Abstract
- Obesity and associated disorders such as type 2 diabetes are a major public health concern worldwide. It is therefore crucial to better understand the underlying mechanisms of these pathologies and to develop new strategies to limit their development. Among the factors involved in obesity, this thesis is focused on the interactions between the intestinal epithelium, the endocannabinoid system and the gut microbiota. The data we obtained give a better understanding of the role of the intestinal endocannabinoid system in the metabolic adaptations to diet-induced obesity. Further, they reinforce our knowledge of the role of the bacterium Akkermansia muciniphila in the regulation of energy homeostasis. Finally, they constitute an important step in the evaluation of therapeutic effects of this bacterium as a tool against the development of obesity.
- Affiliations
Citations
Plovier, H. (2017). Impact of Akkermansia muciniphila and the intestinal endocannabinoid system on the metabolic syndrome. https://hdl.handle.net/2078.5/92189