Serotonin syndrome
(2003) Journal de Pharmacie de Belgique — Vol. 58, n° 2, p. 51-56 (2003)
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- Abstract
- The serotonin syndrome is a hyperserotoninergic state resulting from an excess of intrasynaptic 5-hydroxytryptamine, induced by multiple psychotropic agents, but also non psychiatric drugs. It is a potentially dangerous and sometimes lethal condition. The clinical manifestations usually include cognitive, neuromuscular and autonomic features and are mediated by the action of serotonin on various subtypes of receptors. The main differential diagnosis is the neuroleptic malignant syndrome. Treatment is mainly supportive. No pharmacological agent has been definitively demonstrated really effective. However, reports of cases treated with the 5-HT2 blockers, including cyproheptadine or chlorpromazine have suggested that these agents could have some efficacy. Serotonin syndrome is a toxic condition which requires heightened clinical awareness among physicians in order to prevent, recognize, and treat the condition promptly.
- Affiliations
ULB Hôpital Erasme
Citations
Lheureux, P., Penaloza-Baeza, A., De Cottenier, V., Ullmann, U., & Gris, M. (2003). Serotonin syndrome. Journal de Pharmacie de Belgique, 58(2), 51-56. https://hdl.handle.net/2078.5/239478 (Original work published 2003)