Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease
(2015) Open Forum Infectious Diseases — Vol. 2, n° 2, p. ofv067-ofv067 (2015)
Files
document.pdf
Restricted Access - Adobe PDF
- 351.96 KB
Details
- Authors
- Abstract
- Background. To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to the risk of influenza disease, we conducted a correlate of protection analysis using pooled data from previously published randomized trials. Methods. Data on the occurrence of laboratory-confirmed influenza and HI levels pre- and postvaccination were analyzed from 4 datasets: 3 datasets included subjects aged <65 years who received inactivated trivalent influenza vaccine (TIV) or placebo, and 1 dataset included subjects aged ≥65 years who received AS03-adjuvanted TIV (AS03- TIV) or TIV. A logistic model was used to evaluate the relationship between the postvaccination titer of A/H3N2 HI antibodies and occurrence of A/H3N2 disease. We then built a receiver-operating characteristic curve to identify a potential cutoff titer between protection and no protection. Results. The baseline odds ratio of A/H3N2 disease was higher for subjects aged ≥65 years than <65 years and higher in seasons of strong epidemic intensity than moderate or low intensity. Including age and epidemic intensity as covariates, a 4-fold increase in titer was associated with a 2-fold decrease in the risk of A/H3N2 disease. Conclusions. The modeling exercise confirmed a relationship between A/H3N2 disease and HI responses, but it did not allow an evaluation of the predictive power of the HI response.
- Affiliations
Citations
Benoit, A., Beran, J., Devaster, J.-M., Esen, M., Launay, O., Leroux-Roels, G., McElhaney, J. E., Oostvogels, L., van Essen, G. A., Gaglani, M., Jackson, L. A., Vesikari, T., Legrand, C., Tibaldi, F., Innis, B. L., & Dewe, W. (2015). Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease. Open Forum Infectious Diseases, 2(2), ofv067-ofv067. https://doi.org/10.1093/ofid/ofv067 (Original work published 2015)