A fatal case of suicide with trazodone alone in a 40-year-old patient is reported. Life-threatening arrhythmias, such as torsades de pointes and complete AV block, are recorded. Blood collected at admission contained a trazodone toxic concentration of 25.4 micrograms/mL. The patient developed multiple organ failure and died less than 24 hours after his admission to the emergency department. The authors discuss the effects of overdose of trazodone, a well-known safe antidepressant drug.
de Meester, A., Carbutti, G., Gabriel, L., & Jacques, J. M. (2010). Fatal overdose with trazodone: case report and literature review. Acta Clinica Belgica, 56(4), 258-261. https://doi.org/10.1179/acb.2001.038 (Original work published 2021)