Pancreatic ductal adenocarcinoma (PDAC) is one of the cancers that currently has one of the worst prognoses. It appears mainly from 2 precursor lesions, the pancreatic intraepithelial neoplasia (PanIN), of microscopic appearance, and the intraductal papillary mucinous neoplasms (IPMN), appearing as an association of papillary lesions and large cysts. Its name comes from the fact that it presents ductal structures that recall that of the pancreatic ducts, whose function is to drive the pancreatic secretions produced by the acinar cells to the duodenum. [...]
Jacquemin, P. (2024). On the Effects of Gene Mutations in Pancreatic Tumorigenesis, Depending on the Cell Types and Times When They Are Induced. Cellular and Molecular Gastroenterology and Hepatology, 18(5), 101394 [1-2]. https://doi.org/10.1016/j.jcmgh.2024.101394 (Original work published 2024)