The Bilayer Floating Capsule - a Stomach-directed Drug Delivery System for Misoprostol
(1992) Pharmaceutical Research — Vol. 9, n° 3, p. 298-302 (1992)
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- Abstract
- A bilayer floating dosage unit is proposed to achieve local delivery of misoprostol, a prostaglandin E1 analogue, at the gastric mucosa level. The system is a capsule consisting of a floating layer maintaining the dosage unit buoyant upon the gastric content and a drug layer formulated to act as a sustained-delivery system. The differential design of the two layers allows the optimization of both floating capability and drug release profile. The layers are both composed of a hydrophilic matrix based upon hydroxypropylmethyl cellulose (HPMC). Parameters influencing the release profiles are described. The use of a large capsule increases the gastric residence time (GRT), as it impedes passage through the pylorus opening. gamma-Scintigraphic studies were performed to visualize cohesion of the two layers in vivo and to determine GRT as a function of meal regimen. The average GRTs were 199 +/- 69 min after a single meal (breakfast) and 618 +/- 208 min after a succession of meals.
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Citations
Oth, M., Franz, M., Timmermans, J., & Moes, A. (1992). The Bilayer Floating Capsule - a Stomach-directed Drug Delivery System for Misoprostol. Pharmaceutical Research, 9(3), 298-302. https://doi.org/10.1023/A:1015870314340 (Original work published 1992)