Synthesis of Collagen Nanotubes with Highly Regular Dimensions through Membrane-Templated Layer-by-Layer Assembly.
(2009) Biomacromolecules — Vol. 10, n° 5, p. 1021-1024 (2009)
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- Abstract
- Nanotubes made from a fibrillar protein, namely, collagen, were fabricated by a template-based method combined with layer-by-layer (LbL) deposition. The ability to incorporate collagen in LbL multilayered film was first demonstrated by in situ quartz crystal microbalance and ex situ ellipsometry on a flat model substrate, using poly(styrene sulfonate) (PSS) as polyanion. Collagen-based nanotubes were then fabricated by alternately immersing a polycarbonate membrane, used as template, in PSS and collagen aqueous solutions. Direct evidence for nanotube formation was obtained by dissolving the membrane and imaging the liberated (PSS/collagen)(n) nanostructures by scanning electron microscopy and by transmission electron microscopy. The proposed strategy constitutes a practical alternative to electrospinning as it allows a very good control over the dimensions (outside and inside diameters and length) of the resulting nanotubes. Besides their fundamental interest, collagen-based nanotubes are useful nano-objects for the creation of new nanostructured biomaterials with numerous potential applications in the biomedical field.
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Landoulsi, J., Roy, C., Dupont-Gillain, C. C., & Demoustier, S. (2009). Synthesis of Collagen Nanotubes with Highly Regular Dimensions through Membrane-Templated Layer-by-Layer Assembly. Biomacromolecules, 10(5), 1021-1024. https://doi.org/10.1021/bm900245h (Original work published 2009)