Autoantibodies against granulocyte macrophage colony-stimulating factor and Nocardia infection in solid organ transplant recipients.
(2020) Transplant international — Vol. 33, n° 12, p. 1827-1829 (2020)
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Lebeaux, David 
- Abstract
- Dear Editors, Nocardiosis is a rare but potentially severe bacterial opportunistic infection that may occur after solid organ transplantation (SOT), typically among thoracic transplant recipients and/or in recipients with a high degree of immunosuppression due to anti-rejection therapy [1]. However, nocardiosis may also occur late after transplantation among minimally immunosuppressed patients, suggesting that additional risk factors exist [1]. Recently, autoantibodies against granulocyte macrophage colony-stimulating factor (GM-CSF) have been identified among five previously healthy patients with disseminated nocardiosis [2]. These autoantibodies likely promote nocardiosis by reducing neutrophil and macrophage activation, phagocytosis, and bactericidal activity [2]. We hypothesized that anti-GM-CSF autoantibodies might be involved in post-SOT nocardiosis, especially in patients who apparently have a relatively low degree of immunosuppression. [...]
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Citations
Lebeaux, D., Coussement, J., Chauvet, C., Matignon, M., Scemla, A., Bouvier, N., Dantal, J., Vollaard, A. M., Wunderink, H. F., Van Wijngaerden, E., Naesens, M., Kamar, N., De Greef, J., Guillemain, R., Borie, R., & Candon, S. (2020). Autoantibodies against granulocyte macrophage colony-stimulating factor and Nocardia infection in solid organ transplant recipients. Transplant international, 33(12), 1827-1829. https://doi.org/10.1111/tri.13727 (Original work published 2020)