3-Alkyl-(5,5'-diphenyl)imidazolidineiones as new cannabinoid receptor ligands.

Kanyonyo, M;Govaerts, Sophie;Hermans, Emmanuel;Poupaert, Jacques;Lambert, Didier
(1999) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 9, n° 15, p. 2233-2236 (1999)

Files

pdfdocument.pdf
  • Restricted Access
  • Adobe PDF
  • 237.36 KB
Request a copy

Details

Authors
Abstract
Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Kanyonyo, M., Govaerts, S., Hermans, E., Poupaert, J., & Lambert, D. (1999). 3-Alkyl-(5,5′-diphenyl)imidazolidineiones as new cannabinoid receptor ligands. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 9(15), 2233-2236. https://doi.org/10.1016/S0960-894X(99)00353-4 (Original work published 1999)