<scp>l</scp>-Proline, a resolution agent able to target both enantiomers of mandelic acid: an exciting case of stoichiometry controlled chiral resolution

Zhou, Fuli; Collard, Laurent; Robeyns, Koen; Leyssens, Tom; Shemchuk, Oleksii

doi:10.1039/d2cc02942a

<scp>l</scp>-Proline, a resolution agent able to target both enantiomers of mandelic acid: an exciting case of stoichiometry controlled chiral resolution

Zhou, Fuli

;

Collard, Laurent

;

Robeyns, Koen

;

Leyssens, Tom

;

Shemchuk, Oleksii

(2022) Chemical Communications — Vol. 58, n° 61, p. 8560-8563 (2022)

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Authors

Zhou, FuliUCLouvain
Author
Collard, LaurentUCLouvain
Author
Robeyns, KoenUCLouvain
Author
Leyssens, TomUCLouvain
Author
Shemchuk, OleksiiUCLouvain
Author

Abstract

We present a thought-provoking development in chiral resolution. Using a resolving agent of a given handedness, L-proline, we show that both R- and S-enantiomers of mandelic acid can be resolved from a racemic mixture simply by varying the stoichiometry. We are the first to report this specific feature, achieved by the existence of stoichiometrically diverse cocrystal systems between R- and S-mandelic acid and L-proline.

Affiliations

UCLouvainSST/IMCN/MOST - Molecular Chemistry, Materials and Catalysis

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Zhou, F., Collard, L., Robeyns, K., Leyssens, T., & Shemchuk, O. (2022). <scp>l</scp>-Proline, a resolution agent able to target both enantiomers of mandelic acid: an exciting case of stoichiometry controlled chiral resolution. Chemical Communications, 58(61), 8560-8563. https://doi.org/10.1039/d2cc02942a (Original work published 2022)