Isolated CEP17 Copy Number Gain in Invasive Breast Cancer Results in a "Reverse" Amplification Status.

Van Bockstal, Mieke;Dubois, Dominique;Talpe, Stéphanie;Galant, Christine
(2021) International Journal of Surgical Pathology — Vol. 29, n° 1, p. 76-77 (2021)

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Abstract
Dual-color silver-enhanced in situ hybridization (SISH) is a well-established method for determining the HER2 gene amplification status in invasive breast cancers with equivocal “2+” HER2 protein expression. Dual-color SISH applies 2 different probes on a single tissue slide: a probe for the HER2 gene and a centromere 17 (CEP17) probe. [...]
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Van Bockstal, M., Dubois, D., Talpe, S., & Galant, C. (2021). Isolated CEP17 Copy Number Gain in Invasive Breast Cancer Results in a “Reverse” Amplification Status. International Journal of Surgical Pathology, 29(1), 76-77. https://doi.org/10.1177/1066896920911421 (Original work published 2021)