The contribution of molecular biology in the treatment of laryngopharyngeal reflux: a state of art

Desgain, Olivier;Lawson, Georges;Leveque, Natacha;Remacle, Marc
(2008) Acta Endoscopica — Vol. 38, n° 3, p. 291-294 (2008)

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  • Desgain, OlivierUCLouvain
    Author
  • Lawson, GeorgesUCLouvain
    Author
  • Leveque, NatachaUCLouvain
    Author
  • Remacle, MarcUCLouvain
    Author
Abstract
Today, laryngopharyngeal reflux (LPR) is widely considered as a major cause of laryngeal diseases. Diagnosis and treatment based on the methods used for gastroesophageal reflux disease (GERD) frequently prove to be inefficient. Recently, some authors have been focusing on the specific molecular etiopathology of LPR. They have discovered the presence of H+/K+ ATPase pumps around the submucosa glands of the human larynx. Besides, the lack of carbonic anhydrase in the epithelium of vocal folds in cases of LPR supports the hypothesis according to which reflux-related damages mainly affect the glottic area. Finally, active pepsin and bile acids appear to be strongly involved in inflammation and tumorigenesis related to LPR.
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Desgain, O., Lawson, G., Leveque, N., & Remacle, M. (2008). The contribution of molecular biology in the treatment of laryngopharyngeal reflux: a state of art. Acta Endoscopica, 38(3), 291-294. https://doi.org/10.1007/s101900800007 (Original work published 2008)