MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells.
(2009) PLoS One — Vol. 4, n° 8, p. e6816 (2009)
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- Authors
- Abstract
- Our results demonstrate that miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells. Our data support the view that miR-34 may be involved in pancreatic cancer stem cell self-renewal, potentially via the direct modulation of downstream targets Bcl-2 and Notch, implying that miR-34 may play an important role in pancreatic cancer stem cell self-renewal and/or cell fate determination. Restoration of miR-34 may hold significant promise as a novel molecular therapy for human pancreatic cancer with loss of p53-miR34, potentially via inhibiting pancreatic cancer stem cells.
- Affiliations
autre University of Michigan
Citations
Ji, Q., Hao, X., Zhang, M., Tang, W., Yang, M., Li, L., Xiang, D., Desano, J. T., Bommer, G., Fan, D., Fearon, E. R., Lawrence, T. S., & Xu, L. (2009). MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One, 4(8), e6816. https://doi.org/10.1371/journal.pone.0006816 (Original work published 2009)