Synergistic activation of human T cells by interleukin 1 and interleukin 6.
(1988) European Journal of Immunology — Vol. 18, n° 4, p. 653-656 (1988)
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- Abstract
- Purified human interleukin 6 (IL 6) was found to stimulate the proliferation of human tonsillar and peripheral rosetting T cells subliminally activated with phytohemagglutinin (PHA). This response seemed independent of IL 2 but highly dependent on the presence of accessory cells. Indeed, when accessory cell-depleted tonsillar T cells were activated with PHA and exposed to IL 6, only minimal proliferations were observed. A similar result was obtained with IL 1. However, a combination of these two cytokines induced strong proliferations, indicating that IL 1 and IL 6 plays a synergistic role in the interactions between accessory cells and T lymphocytes.
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Houssiau, F., Coulie, P., Olive, D., & Van Snick, J. (1988). Synergistic activation of human T cells by interleukin 1 and interleukin 6. European Journal of Immunology, 18(4), 653-656. https://doi.org/10.1002/eji.1830180427 (Original work published 1988)