Interleukin-9 stimulates the production of interleukin-5 in CD4(+) T cells
(2005) European Cytokine Network — Vol. 16, n° 3, p. 233-239 (2005)
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- We recently showed that interleukin-9 (IL-9), a Th2 cytokine, promotes IL-5-mediated rejection of allografts in mice. This observation led us to investigate the functional link between IL-9 and IL-5 production during alloreactive T cell responses in vitro and in vivo. Firstly, we found that IL-9 was produced by alloreactive Th2 cells, and IL-9 mRNA was detected in skin allograft during Th2-type rejection. We then established that IL-5 production was impaired in alloreactive Th2 cells isolated from IL-9-deficient mice and that optimal IL-5 production after allogeneic stimulation requires a functional IL-9 receptor (IL-9R) on the responding cells. Finally, the production of IL-5 by anti-CD3-stimulated CD4(+) T cells was abolished by neutralization of IL-9. Despite the fact that IL-9 promotes IL-5 production by alloreactive T cells, IL-9-deficient recipients of skin allografts still developed eosinophilic graft infiltrates and neither IL-9 nor IL-9R deficiency modified Th2-type allograft rejection.
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Poulin, L., Habran, C., Stordeur, P., Goldman, M., McKenzie, A., Van Snick, J., Renauld, J.-C., & Braun, M. (2005). Interleukin-9 stimulates the production of interleukin-5 in CD4(+) T cells. European Cytokine Network, 16(3), 233-239. https://hdl.handle.net/2078.5/96266 (Original work published 2005)