Near full-length characterization and population dynamics of the human immunodeficiency virus type I circulating recombinant form 42 (CRF42-BF) in Luxembourg
(2015) AIDS Research and Human Retroviruses — Vol. 31, n° 5, p. 554-558 (2015)
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- (en) A new recombinant form representing a mosaic of HIV-1 subtype B and F1 and designated as CRF42_BF was identified in Luxembourg. We confirmed the inedited nature of CRF42_BF by near full-length genome characterization and retrieved a possible ancestor originating from Brazil. The demographic history of CRF42_BF in Luxembourg using Bayesian coalescent-based methods was investigated. The exponential phase of the logistic growth happened in a very short time period of approximately 5 months associated with a high mean rate of population growth of 15.02 new infections per year. However, CRF42_BF was not characterized by either a higher ex vivo replication capacity in peripheral blood mononuclear cells (PBMCs) or a higher ex vivo transmission efficiency from monocyte-derived dendritic cells to PBMCs as compared to B and F1 viruses. These data do not support a high pathogenic potential of CFR42_BF but rather an initial bursting spread of the recombinant probably due to a more favorable transmission route.
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Struck, D., Roman, F., De Landtsheer, S., Servais, J.-Y., Lambert, C., Masquelier, C., Venard, V., & Ruelle, J. (2015). Near full-length characterization and population dynamics of the human immunodeficiency virus type I circulating recombinant form 42 (CRF42-BF) in Luxembourg. AIDS Research and Human Retroviruses, 31(5), 554-558. https://doi.org/10.1089/aid.2014.0364 (Original work published 2015)