Spatial Transcriptomic Analysis of Surgical Resection Specimens of Primary Head and Neck Squamous Cell Carcinoma Treated with Afatinib in a Window-of-Opportunity Study (EORTC90111-24111)

Beyaert, Simon;Loriot, Axelle;Machiels, Jean-Pascal;Schmitz, Sandra
(2025) International Journal of Molecular Sciences — Vol. 26, n° 5, p. 1830 (2025)

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Abstract
Afatinib-induced tumor and microenvironment modifications in head and neck squamous cell carcinoma were evaluated by spatial transcriptomics in surgical specimens and RNA-sequencing in tumor biopsies of patients included in the EORTC-90111-24111 window-of-opportunity study.
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Beyaert, S., Loriot, A., Machiels, J.-P., & Schmitz, S. (2025). Spatial Transcriptomic Analysis of Surgical Resection Specimens of Primary Head and Neck Squamous Cell Carcinoma Treated with Afatinib in a Window-of-Opportunity Study (EORTC90111-24111). International Journal of Molecular Sciences, 26(5), 1830. https://doi.org/10.3390/ijms26051830 (Original work published 2025)