Plasma atrial natriuretic factor and catecholamines before and during excision of pheochromocytoma.
(1991) Acta Chirurgica Belgica (Bilingual Edition) — Vol. 91, n° 2, p. 112-116 (1991)
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- We studied changes of atrial natriuretic factor (ANF) and catecholamines in three patients with pheochromocytoma occurring in the familial syndrome of multiple endocrine neoplasia type IIa. Previous studies have suggested a stimulating effect of catecholamines on ANF release. In pheochromocytoma, we observed normal basal ANF levels despite increased catecholamine secretion. In contrast, a rise in plasma ANF was observed when a hypertensive paroxysm occurred. Also during surgery, dissection of pheochromocytoma led to a rise in plasma ANF and catecholamines associated with an increase in blood pressure (in the 3 cases) and in pulmonary artery pressure (in 2 cases). We concluded that chronic elevation of basal catecholamines are without effect on plasma ANF but that manipulation of pheochromocytoma leads to a stimulation of ANF release, possibly mediated by either a direct effect of endogenously released catecholamines and/or an increase in atrial pressure.
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Donckier, J., Michel, L., Collard, E., Galanti, L., Harvengt, C., Berbinschi, A., Ketelslegers, J.-M., & Buysschaert, M. (1991). Plasma atrial natriuretic factor and catecholamines before and during excision of pheochromocytoma. Acta Chirurgica Belgica (Bilingual Edition), 91(2), 112-116. https://hdl.handle.net/2078.5/70758 (Original work published 1991)