No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood.

Léonard, Alain;Gerber, G B;Crutzen-Fayt, M C;Richard, Françoise;Akhmatullina, N B;et.al.
(1998) Mutation Research — Vol. 420, n° 1-3, p. 33-36 (1998)

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  • Léonard, AlainUCLouvain
    Author
  • Gerber, G B
    Author
  • Crutzen-Fayt, M C
    Author
  • Richard, FrançoiseUCLouvain
    Author
  • Gueulette, JohnUCLouvain
    Author
  • Akhmatullina, N B
    Author
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Abstract
Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood given 4 Gy of X-rays in vitro and with plasma from people receiving local radiotherapy at a total dose of about 60 Gy gamma rays. Addition of irradiated plasma to culture medium did not result in a statistically significant increase in structural aberrations in chromosomes of non-irradiated normal blood.
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Léonard, A., Gerber, G. B., Crutzen-Fayt, M. C., Richard, F., Gueulette, J., & Akhmatullina, N. B. (1998). No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood. Mutation Research, 420(1-3), 33-36. https://hdl.handle.net/2078.5/94159 (Original work published 1998)