Experiments were performed with human plasma irradiated in vitro or in vivo in order to evaluate the extent to which clastogenic factors might disturb the adaptive response to DNA-damaging factors currently studied in our laboratory. The studies were carried out with plasma isolated from whole blood given 4 Gy of X-rays in vitro and with plasma from people receiving local radiotherapy at a total dose of about 60 Gy gamma rays. Addition of irradiated plasma to culture medium did not result in a statistically significant increase in structural aberrations in chromosomes of non-irradiated normal blood.
Léonard, A., Gerber, G. B., Crutzen-Fayt, M. C., Richard, F., Gueulette, J., & Akhmatullina, N. B. (1998). No evidence for radiation-induced clastogenic factors after in vitro or in vivo exposure of human blood. Mutation Research, 420(1-3), 33-36. https://hdl.handle.net/2078.5/94159 (Original work published 1998)