Synthesis of pyrazino[1,2-a]benzimidazol-1(2H)ones via a microwave assisted Buchwald-Hartwig type reaction

Alen, Jo;Robeyns, Koen;De Borggraeve, Wim M.;Van Meervelt, Luc;Compernolle, Frans
(2008) Tetrahedron — Vol. 64, n° 35, p. 8128-8133 (2008)

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Authors
  • Alen, JoKU LEUVEN
    Author
  • Robeyns, KoenUCLouvain
    Author
  • De Borggraeve, Wim M.
    Author
  • Van Meervelt, Luc
    Author
  • Compernolle, Frans
    Author
Abstract
A convenient synthesis of substituted pyrazino[1,2-a]benzimidazol-1(2H)ones starting from 3,5-dichloropyrazinones has been accomplished. Various 3-anilino-pyrazinones were easily converted to the desired tricyclic structures by applying a microwave assisted Buchwald-Hartwig type cyclization. © 2008 Elsevier Ltd. All rights reserved.
Affiliations
  • KU LEUVENDepartment of Chemistry

Citations

Alen, J., Robeyns, K., De Borggraeve, W. M., Van Meervelt, L., & Compernolle, F. (2008). Synthesis of pyrazino[1,2-a]benzimidazol-1(2H)ones via a microwave assisted Buchwald-Hartwig type reaction. Tetrahedron, 64(35), 8128-8133. https://doi.org/10.1016/j.tet.2008.06.056 (Original work published 2008)