Effect of serious games over conventional therapy in the rehabilitation of people with multiple sclerosis – a systematic review and meta-analysis
(2025) Disability and Rehabilitation — Vol. 47, n° 13, p. 3224-3244 (2025)
Files
Copywithrevisions2.pdf
Preprint
Open Access - Adobe PDF
- 1.81 MB
Details
- Authors
- Abstract
- (en) PURPOSE: This meta-analysis aimed to quantify the effect of serious games over conventional therapy on upper-limb activity, balance, gait, fatigue, and cognitive functions in people with multiple sclerosis. MATERIALS AND METHODS: Search strategies were developed for PubMed, Embase, Cochrane Library, and Scopus. Studies were selected if participants were adults with multiple sclerosis; the intervention consisted of a virtual reality serious game-based program; the control group received conventional therapy; outcomes included upper limb activity, balance, gait, fatigue, or cognitive functions; and used a randomized controlled trial design. Data were synthesized using a standardized mean difference with a random-effects model. RESULTS: From 2532 studies, seventeen trials were selected (n = 740). Overall, serious games programs effect on upper limb activity, gait, verbal memory, verbal fluency and attention seemed neutral. Balance functions appeared to be improved by semi-immersive virtual reality serious games (SMD = 0.48;95%CI = 0.12-0.84;p = 0.01;I2=0%), fatigue by treadmill serious games (SMD = 0.80;95%CI = 0.40-1.20;p < 0.001) and visuo-spatial memory by semi-immersive virtual reality general cognitive serious games (SMD = 0.35;95%CI = 0.04-0.65;p = 0.03;I2=0%). CONCLUSION: This review suggests, with a very-low-to-low certainty of evidence, that while some specific serious games may improve balance, fatigue and visuo-spatial memory, their overall effect on upper limb activity, gait, and other cognitive functions appears neutral.
- Affiliations
Université Laval Centre interdisciplinaire de recherche en réadaptation et intégration sociale
Citations
Saragih, I. D., Gervais Willy, Lamora, J.-P., Batcho, C. S., & Everard, G. (2025). Effect of serious games over conventional therapy in the rehabilitation of people with multiple sclerosis – a systematic review and meta-analysis. Disability and Rehabilitation, 47(13), 3224-3244. https://doi.org/10.1080/09638288.2024.2415328 (Original work published 2025)