Use of sodium ascorbate and poly I:C in conjunction with a mycobacterial antigen complex as cancer preventive immunotherapy
(1996) Journal of Experimental and Clinical Cancer Research — Vol. 15, n° 2, p. 197-205 (1996)
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- Abstract
- It has been previously shown that mice pretreated with A60, an immunodominant mycobacterial antigen complex, show increased resistance to implantation of various tumor types. It is also known that vitamin C and poly I:C also have antitumor activities. This study was conducted to determine whether these two products, utilized as adjuvant pretreatments with A60, could act synergistically and increase resistance to tumor implantation. Mice were immunized with the three substances in different combinations before tumor challenge. Afterwards, oncological indexes, antibody productions, delayed type hypersensitivity reactions, lymphocyte proliferations and macrophage activations were measured. The results of these investigations show that each factor, used separately as complementary pretreatments to A60, significantly increase immune responses and survival rates, and that the effects are even stronger when complete pretreatment, with all three substances, is performed.
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Maes, H., & Taper, HS. (1996). Use of sodium ascorbate and poly I:C in conjunction with a mycobacterial antigen complex as cancer preventive immunotherapy. Journal of Experimental and Clinical Cancer Research, 15(2), 197-205. https://hdl.handle.net/2078.5/70910 (Original work published 1996)