Diagnostic et prise en charge de la variabilité de la réponse au clopidogrel dans l'artériopathie oblitérante des membres inférieurs: Illustrations cliniques et revue de la littérature

Yildiz, Halil;Vandeleene, Bernard;Lambert, Catherine;Gala, Jean-Luc;Hermans, Cédric
(2015) Louvain médical — Vol. 134, n° 1, p. 7-12 (2015)

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(en) [Diagnosis and management of variable clopidogrel response in obliterating arteriopathy of the lower limbs: clinical illustrations and literature review] We report the case of two patients with diabetes mellitus who attended our hospital consultation for chronic peripheral artery disease (stent thrombosis) in spite of antiplatelet drug treatment (clopidogrel 75mg, aspirin 8 mg). A blood aggregometry with ADP was performed revealing high residual platelet reactivity. A genetic polymorphisms in the hepatic enzymes (CYP2C19 ; PON-1) involved in clopidogrel metabolism was identified. After adjusting the clopidogrel dose, both a biological and clinical response was observed.
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Yildiz, H., Vandeleene, B., Lambert, C., Gala, J.-L., & Hermans, C. (2015). Diagnostic et prise en charge de la variabilité de la réponse au clopidogrel dans l’artériopathie oblitérante des membres inférieurs: Illustrations cliniques et revue de la littérature. Louvain médical, 134(1), 7-12. https://hdl.handle.net/2078.5/185299 (Original work published 2015)