Factors associated with Prolonged Inaction in the hypoglycaemic treatment in people with non-insulin dependent Type 2 Diabetes and elevated glycated haemoglobin: A registry-based cohort study

Goderis, Geert;Vaes, Bert;Van den Akker, Marjan;Elli, Steven;Henrard, Séverine;et.al.
(2017) Primary Care Diabetes — Vol. 11, n° 5, p. 482-489 (2017)

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Authors
  • Goderis, Geert
    Author
  • Vaes, Bert
    Author
  • Van den Akker, Marjan
    Author
  • Elli, Steven
    Author
  • Henrard, Séverineorcid-logoUCLouvain
    Author
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Abstract
Aims To assess factors associated with Prolonged Inaction (PI) in insulin-naïve patients with Type 2 Diabetes Mellitus (T2DM). PI was defined as the absence of treatment initiation or intensification for ≥12 months despite HbA1c >7% (53 mmol/mol). Methods A retrospective cohort study was conducted based on data from Intego, a Flemish General Practice registry. The study period ranged from January 1, 2006 to December 31, 2013. Patients with insulin therapy before the start of the study period were excluded from the analysis. A mixed effects logistic regression was used to assess the association of PI with the presence of co-morbidities, co-medications, process parameters and bio-clinical parameters. Results In a population of 2265 patients with T2DM, 578 insulin-naive patients presented with an HbA1c >7% (53 mmol/mol) for ≥12 months. Median follow-up was 1.2 years, median age 67 years, 55% were male. PI was present in 340 patients (59%) and associated with moderate to severe Chronic Kidney Disease, absence of a mental health disorder, less frequent HbA1c measurements, lower HbA1c values and a smaller number of co-medications. Conclusions PI is highly prevalent in primary care, particularly in patients with less complex disease status and with less intensive follow-up.
Affiliations
  • KU Leuven (KUL)Department of General Practice
  • Maastricht UniversityDepartment of Family Medicine, School CAPHRI
  • University Hospitals, KU LeuvenUnit of Clinical and Experimental Endocrinology

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Goderis, G., Vaes, B., Van den Akker, M., Elli, S., Mathieu, C., Buntinx, F., & Henrard, S. (2017). Factors associated with Prolonged Inaction in the hypoglycaemic treatment in people with non-insulin dependent Type 2 Diabetes and elevated glycated haemoglobin: A registry-based cohort study. Primary Care Diabetes, 11(5), 482-489. https://doi.org/10.1016/j.pcd.2017.05.008 (Original work published 2017)