A 53-year-old woman suffered six episodes of Clostridium difficile-pseudomembranous colitis. The serological follow-up demonstrated the absence of a rise in IgG and IgA to toxin A. Human pooled gamma globulin was administered during the fifth relapse and raised IgG levels to toxin A. Normal stools reappeared a week later. The role of the antibodies to toxin A and gamma globulin in C. difficile colitis are discussed.
Warny, M., Denie, C., Delmée, M., & Lefebvre, C. (1995). Gamma globulin administration in relapsing Clostridium difficile-induced pseudomembranous colitis with a defective antibody response to toxin A. Acta Clinica Belgica (Multilingual Edition), 50(1), 36-39. https://hdl.handle.net/2078.5/134755 (Original work published 1995)