Captopril and S-nitrosocaptopril as potent radiosensitizers : comparative study and underlying mechanisms
(2010) Cancer Letters — Vol. 293, n° 2, p. 213-219 (2010)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 441.86 KB
Details
- Authors
- Abstract
- In an effort to improve the issue of radiotherapy treatments, we tested whether S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic status of experimental tumors. We monitored the effect of S-nitrosocaptopril in TLT tumors using non rinvasive magnetic resonance techniques. We identified a time window during which tumor oxygenation was improved, as a result of a combined effect on tumor blood flow and oxygen consumption. Consequently, the administration of S-nitrosocaptopril contributed to the increase in efficacy of radiation therapy, an effect that was not observed with captopril alone.
- Affiliations
Citations
Jordan, B., Peeterbroeck, J., Karroum, O., Diépart, C., Magat, J., Grégoire, V., & Gallez, B. (2010). Captopril and S-nitrosocaptopril as potent radiosensitizers : comparative study and underlying mechanisms. Cancer Letters, 293(2), 213-219. https://doi.org/10.1016/j.canlet.2010.01.016 (Original work published 2010)