Anti-Parasitic Activity of Essential Oils and their Active Constituents against Plasmodium, Trypanosoma and Leishmania
(2014) Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics — ISBN: [978-1-118-46061-0], p. 455-469, published
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- Plants and essential oils are used in traditional medicine against parasitic diseases. This review highlights some essential oils and their constituents. The activities are graded as good (IC50 < 2 g/ml or µM) or moderate (IC50 < 21 µg/ml or µM) against at least one parasite. A literature review indicates 123 essential oils as being antiparasitic in vitro on at least one parasite. Some oils were tested for their cytotoxicity but few for their in vivo antiparasitic effect. This review highlights their potential as a source of new antiparasitic compounds. Fifty volatile pure compounds were separately tested against at least one of three parasites. Among them, five compounds - ?-pinene, linalylacetate, (E,Z) (±)-nerolidol, (?)-pulegone and thymoquinone - showed a good antiplasmodial activity. The most active were the sesquiterpenic alcohols, (E,Z) (±)-nerolidol with IC50 = 0.9 M. Only (±)-linalool showed good antileishmanial effect and (?)-terpinen-4-ol a good antitrypanosomal activity.
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Bero, J., Kpoviessi, S., & Quetin-Leclercq, J. (2014). Anti-Parasitic Activity of Essential Oils and their Active Constituents against Plasmodium, Trypanosoma and Leishmania. In Ameenah Gurib-Fakim (ed.), Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics (p. p. 455-469). JohnWiley & Sons. https://doi.org/10.1002/9781118460566.ch33