T cell-based cancer immunotherapy relies on advancements made over the last 20 years on the molecular mechanisms underlying the antigenicity of tumors. This review focuses on human tumor antigens recognized by T lymphocytes, particularly the reasons why some are tumor-specific but others are not, and on the immunologic adjuvants used in clinical trials on therapeutic vaccination with defined tumor antigens.
Seremet, T., Brasseur, F., & Coulie, P. (2011). Tumor-specific antigens and immunologic adjuvants in cancer immunotherapy. The Cancer Journal, 17(5), 325-330. https://doi.org/10.1097/PPO.0b013e3182326004 (Original work published 2011)