Periostin is strongly expressed by fibroblasts and deposited in the peritoneal cavity of patients with EPS and with simple peritoneal fibrosis on PD. This protein might play a role in the progression of peritoneal injury, and low levels of periostin after prolonged time on PD might be a marker of EPS.
Braun, N., Sen, K., Alscher, M. D., Fritz, P., Kimmel, M., Morelle, J., Goffin, E., Jörres, A., Wüthrich, R. P., Cohen, C. D., & Segerer, S. (2013). Periostin: a matricellular protein involved in peritoneal injury during peritoneal dialysis. Peritoneal Dialysis International, 33(5), 515-528. https://doi.org/10.3747/pdi.2010.00259 (Original work published 2013)