Hydrazine selective dual signaling chemodosimetric probe in physiological conditions and its application in live cells

Nandi, S.;Sahana, A.;Mandal, S.;Sengupta, A.;Das, D.;et.al.
(2015) Analytica Chimica Acta — Vol. 893, p. 84-90 (2015)

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Authors
  • Nandi, S.University of Burdwan (India)
    Author
  • Sahana, A.University of Burdwan (India)
    Author
  • Mandal, S.University of Burdwan (India)
    Author
  • Sengupta, A.Visva Bharati University (India)
    Author
  • Safin, DamirUCLouvain
    Author
  • Babashkina, MariaUCLouvain
    Author
  • Tumanov, NikolayUCLouvain
    Author
  • Filinchuk, YaroslavUCLouvain
    Author
  • Das, D.University of Burdwan (India)
    Author
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Abstract
A rhodamineecyanobenzene conjugate, (E)-4-((2-(30,60-bis(diethylamino)-3-oxospiro[isoindoline-1,90-xanthene]-2-yl)ethylimino)methyl)benzonitrile (1), which structure has been elucidated by single crystal X-ray diffraction, was synthesized for selective fluorescent “turn-on” and colorimetric recognition of hydrazine at physiological pH 7.4. It was established that 1 detects hydrazine up to 58 nM. The probe is useful for the detection of intracellular hydrazine in the human breast cancer cells MCF-7 using a fluorescence microscope. Spirolactam ring opening of 1, followed by its hydrolysis, was established as a probable mechanism for the selective sensing of hydrazine.
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Nandi, S., Sahana, A., Mandal, S., Sengupta, A., Chatterjee, A., Safin, D., Babashkina, M., Tumanov, N., Filinchuk, Y., & Das, D. (2015). Hydrazine selective dual signaling chemodosimetric probe in physiological conditions and its application in live cells. Analytica Chimica Acta, 893, 84-90. https://doi.org/10.1016/j.aca.2015.08.041 (Original work published 2015)