Activation of rat heart phosphofructokinase-2 by insulin in vivo.

Rider, Mark H.;Hue, Louis
(1984) FEBS Letters — Vol. 176, n° 2, p. 484-488 (1984)

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Authors
  • Rider, Mark H.UCLouvain
    Author
  • Hue, LouisUCLouvain
    Author
Abstract
Fifteen minutes after the intravenous injection of overnight starved, anaesthetized rats with insulin, the concentration of fructose 2,6-biphosphate was increased more than 2-fold in the hearts of these animals. Insulin injection also caused a 2-3 fold increase in the Vmax of phosphofructokinase-2 with no detectable change in Km values. The effect persisted after precipitation of the enzyme with polyethylene glycol or after gel filtration through Sephadex G-25.
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Rider, M. H., & Hue, L. (1984). Activation of rat heart phosphofructokinase-2 by insulin in vivo. FEBS Letters, 176(2), 484-488. https://doi.org/10.1016/0014-5793(84)81223-5 (Original work published 1984)