Synthesis and Characterization of New Polyethyleneoxy Substituted Salicylaldimine Schiff-bases and Some Corresponding Reduced Tetra-aza and Penta-aza Ligands and Their Gadolinium(iii) Complexes - New Potential Contrast Agents in Magnetic-resonance-imaging

Kocian, O.;Chiu, KW.;Demeure, R.;Gallez, Bernard;Thornback, JR.;et.al.
(1994) Royal Society of Chemistry. Journal: Perkin Transactions 1 — n° 5, p. 527-535 (1994)

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  • Kocian, O.
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  • Chiu, KW.
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  • Demeure, R.
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  • Gallez, Bernardorcid-logoUCLouvain
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  • Thornback, JR.
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Abstract
A series of polyether substituted salicylaldehyde derivatives OHCC6H3OH-2-OR-3 [R = CH2-(CH2OCH2)(n)CH(2)OR', n = 1, 4 and R' = Me; n = 5 and R'= H] have been synthesised and used to prepare the polydentate ligands HN[(CH2CH2NHCH2CH2N=CHC6H3OH-2-OR-3](2), HN[CH2CH2NHCH2CH2NHCH2C6H3-OH-2-OR-3](2) and HN[CH2CH2N=CHC6H3OH-2-OR-3](3); a preliminary evaluation has been made of the potential use of their gadolinium complexes as contrast agents for diagnostic Magnetic Resonance Imaging.
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Kocian, O., Chiu, KW., Demeure, R., Gallez, B., Jones, CJ., & Thornback, JR. (1994). Synthesis and Characterization of New Polyethyleneoxy Substituted Salicylaldimine Schiff-bases and Some Corresponding Reduced Tetra-aza and Penta-aza Ligands and Their Gadolinium(iii) Complexes - New Potential Contrast Agents in Magnetic-resonance-imaging. Royal Society of Chemistry. Journal: Perkin Transactions 1, 5, 527-535. https://doi.org/10.1039/p19940000527 (Original work published 1994)